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<t>ADSC-Exs</t> promote LECs proliferation, migration, and tube formation. ( A ) Representative images of Transwell invasion and migration assays, tube formation and KVA analysis between LECs treated with PBS (LEC + PBS) and ADSC-derived exosomes (LEC + Exo). Scale bar = 200 μm. ( B–C ) Cell viability of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( D ) Proliferation of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( E ) Transwell assays were used to determine the effect of ADSC-Exs on LECs invation and migration. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Two-way ANOVA and Sidak’s multiple comparisons test were applied. ( F–G ) Tube formation parameters quantified by KAV about the number of nodes, junctions and total tube length between the two groups. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. *P < 0.05, **P 0.01, ***P < 0.001. LECs: lymphatic endothelial cell; <t>Exo:</t> <t>exosome.</t>

Adsc Group Adsc, supplied by Exosome Diagnostics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/adsc+group+adsc/pmc12858794-144-17-21?v=Exosome+Diagnostics
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adsc group adsc - by Bioz Stars, 2026-06

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1) Product Images from "Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema"

Article Title: Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema

Journal: Scientific Reports

doi: 10.1038/s41598-025-34280-0

ADSC-Exs promote LECs proliferation, migration, and tube formation. ( A ) Representative images of Transwell invasion and migration assays, tube formation and KVA analysis between LECs treated with PBS (LEC + PBS) and ADSC-derived exosomes (LEC + Exo). Scale bar = 200 μm. ( B–C ) Cell viability of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( D ) Proliferation of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( E ) Transwell assays were used to determine the effect of ADSC-Exs on LECs invation and migration. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Two-way ANOVA and Sidak’s multiple comparisons test were applied. ( F–G ) Tube formation parameters quantified by KAV about the number of nodes, junctions and total tube length between the two groups. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. *P < 0.05, **P 0.01, ***P < 0.001. LECs: lymphatic endothelial cell; Exo: exosome.

Figure Legend Snippet: ADSC-Exs promote LECs proliferation, migration, and tube formation. ( A ) Representative images of Transwell invasion and migration assays, tube formation and KVA analysis between LECs treated with PBS (LEC + PBS) and ADSC-derived exosomes (LEC + Exo). Scale bar = 200 μm. ( B–C ) Cell viability of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( D ) Proliferation of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( E ) Transwell assays were used to determine the effect of ADSC-Exs on LECs invation and migration. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Two-way ANOVA and Sidak’s multiple comparisons test were applied. ( F–G ) Tube formation parameters quantified by KAV about the number of nodes, junctions and total tube length between the two groups. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. *P < 0.05, **P 0.01, ***P < 0.001. LECs: lymphatic endothelial cell; Exo: exosome.

Techniques Used: Migration, Derivative Assay, Comparison

Edema levels of the different groups at the 5th week. ( A ) Experimental groups and respective interventions at different time points. ( B ) Diameter measurement with a caliper. ( C ) Volume measurement with water displacement. ( D ) Diameter statistics for the different groups at different time points. (n = 3) ( E ) Circumference statistics for the different groups at different time points. (n = 3) ( F ) Volume statistics for the different groups at different time points. (n = 8) Pairwise comparisons among group Sham, SLE, ADSC, ADSC-Ex and EW were performed separately at week 0, + 1, + 2, + 3, + 4, and week + 5. n = 8 for each group. Two-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Figure Legend Snippet: Edema levels of the different groups at the 5th week. ( A ) Experimental groups and respective interventions at different time points. ( B ) Diameter measurement with a caliper. ( C ) Volume measurement with water displacement. ( D ) Diameter statistics for the different groups at different time points. (n = 3) ( E ) Circumference statistics for the different groups at different time points. (n = 3) ( F ) Volume statistics for the different groups at different time points. (n = 8) Pairwise comparisons among group Sham, SLE, ADSC, ADSC-Ex and EW were performed separately at week 0, + 1, + 2, + 3, + 4, and week + 5. n = 8 for each group. Two-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Techniques Used:

ADSC-Ex promotes lymphatic endothelial proliferation in secondary lymphedema. ( A ) Representative immunofluorescence images of edematous skin sections stained for podoplanin (red), Ki67 (green), and DAPI (blue). Scale bar = 100 μm. ( B–C ) Quantification of podoplanin⁺ and Ki67⁺ positive areas. ( D–E ) Mean fluorescence intensity of podoplanin and Ki67. ( F–H ) Colocalization analysis showing the highest overlap coefficient in the ADSC-Ex group, followed by ADSC, with minimal overlap in EW and SLE groups. Pairwise comparisons among group Sham, SLE, ADSC, ADSC-Ex and group EW, n = 8 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001, ****P < 0.001, n = 3.

Figure Legend Snippet: ADSC-Ex promotes lymphatic endothelial proliferation in secondary lymphedema. ( A ) Representative immunofluorescence images of edematous skin sections stained for podoplanin (red), Ki67 (green), and DAPI (blue). Scale bar = 100 μm. ( B–C ) Quantification of podoplanin⁺ and Ki67⁺ positive areas. ( D–E ) Mean fluorescence intensity of podoplanin and Ki67. ( F–H ) Colocalization analysis showing the highest overlap coefficient in the ADSC-Ex group, followed by ADSC, with minimal overlap in EW and SLE groups. Pairwise comparisons among group Sham, SLE, ADSC, ADSC-Ex and group EW, n = 8 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001, ****P < 0.001, n = 3.

Techniques Used: Immunofluorescence, Staining, Fluorescence

Fibrosis levels of the different groups at the 5th week ( A ) Fibrosis level of the different groups, as determined by Masson and Sirus red staining with the common light microscope and polarizing microscope. Scale bar = 200 μm. ( B ) Fibrosis positive area statistics of Masson staining. ( C ) Fibrosis positive area statistics of Sirus red staining. Group Sham, SLE, ADSC, ADSC-Ex and group EW were compared with one another, n = 3 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Figure Legend Snippet: Fibrosis levels of the different groups at the 5th week ( A ) Fibrosis level of the different groups, as determined by Masson and Sirus red staining with the common light microscope and polarizing microscope. Scale bar = 200 μm. ( B ) Fibrosis positive area statistics of Masson staining. ( C ) Fibrosis positive area statistics of Sirus red staining. Group Sham, SLE, ADSC, ADSC-Ex and group EW were compared with one another, n = 3 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Techniques Used: Staining, Light Microscopy, Microscopy

ADSC-Ex attenuates fibrosis by suppressing TGF-β1/Smad signaling in edematous skin. ( A ) Representative Western blot images of TGF-β/smad signaling-related proteins in edematous regions, (TGFβ1, Smad2/3, P-Smad2/3 and Smad7). ( B – E ) Representative density analysis of the TGF-β/smad signaling-related proteins in edematous regions, (TGFβ1, Smad2/3, P-Smad2/3 and Smad7). Group Sham, SLE, ADSC, ADSC-Ex and group EW were compared with one another, n = 3 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Figure Legend Snippet: ADSC-Ex attenuates fibrosis by suppressing TGF-β1/Smad signaling in edematous skin. ( A ) Representative Western blot images of TGF-β/smad signaling-related proteins in edematous regions, (TGFβ1, Smad2/3, P-Smad2/3 and Smad7). ( B – E ) Representative density analysis of the TGF-β/smad signaling-related proteins in edematous regions, (TGFβ1, Smad2/3, P-Smad2/3 and Smad7). Group Sham, SLE, ADSC, ADSC-Ex and group EW were compared with one another, n = 3 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Techniques Used: Western Blot

Image Search Results

Journal: Scientific Reports

Article Title: Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema

doi: 10.1038/s41598-025-34280-0

Figure Lengend Snippet: ADSC-Exs promote LECs proliferation, migration, and tube formation. ( A ) Representative images of Transwell invasion and migration assays, tube formation and KVA analysis between LECs treated with PBS (LEC + PBS) and ADSC-derived exosomes (LEC + Exo). Scale bar = 200 μm. ( B–C ) Cell viability of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( D ) Proliferation of LECs measured at 24 h and 48 h after treatment. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. ( E ) Transwell assays were used to determine the effect of ADSC-Exs on LECs invation and migration. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Two-way ANOVA and Sidak’s multiple comparisons test were applied. ( F–G ) Tube formation parameters quantified by KAV about the number of nodes, junctions and total tube length between the two groups. Group LEC + PBS was compared with Group LEC + Exo, with n = 3 for each group. Unpaired t tests and no multiple-comparison correction were applied. *P < 0.05, **P 0.01, ***P < 0.001. LECs: lymphatic endothelial cell; Exo: exosome.

Article Snippet: In our study, C57BL/6 mice were divided into five groups: the sham-operated group (Sham), SLE group (SLE), ADSC group (ADSC), ADSC-derived exosome group (ADSC-Exs), and EW-7197 treatment group (EW).

Techniques: Migration, Derivative Assay, Comparison

Journal: Scientific Reports

Article Title: Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema

doi: 10.1038/s41598-025-34280-0

Figure Lengend Snippet: Edema levels of the different groups at the 5th week. ( A ) Experimental groups and respective interventions at different time points. ( B ) Diameter measurement with a caliper. ( C ) Volume measurement with water displacement. ( D ) Diameter statistics for the different groups at different time points. (n = 3) ( E ) Circumference statistics for the different groups at different time points. (n = 3) ( F ) Volume statistics for the different groups at different time points. (n = 8) Pairwise comparisons among group Sham, SLE, ADSC, ADSC-Ex and EW were performed separately at week 0, + 1, + 2, + 3, + 4, and week + 5. n = 8 for each group. Two-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Techniques:

Journal: Scientific Reports

Article Title: Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema

doi: 10.1038/s41598-025-34280-0

Figure Lengend Snippet: ADSC-Ex promotes lymphatic endothelial proliferation in secondary lymphedema. ( A ) Representative immunofluorescence images of edematous skin sections stained for podoplanin (red), Ki67 (green), and DAPI (blue). Scale bar = 100 μm. ( B–C ) Quantification of podoplanin⁺ and Ki67⁺ positive areas. ( D–E ) Mean fluorescence intensity of podoplanin and Ki67. ( F–H ) Colocalization analysis showing the highest overlap coefficient in the ADSC-Ex group, followed by ADSC, with minimal overlap in EW and SLE groups. Pairwise comparisons among group Sham, SLE, ADSC, ADSC-Ex and group EW, n = 8 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001, ****P < 0.001, n = 3.

Techniques: Immunofluorescence, Staining, Fluorescence

Journal: Scientific Reports

Article Title: Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema

doi: 10.1038/s41598-025-34280-0

Figure Lengend Snippet: Fibrosis levels of the different groups at the 5th week ( A ) Fibrosis level of the different groups, as determined by Masson and Sirus red staining with the common light microscope and polarizing microscope. Scale bar = 200 μm. ( B ) Fibrosis positive area statistics of Masson staining. ( C ) Fibrosis positive area statistics of Sirus red staining. Group Sham, SLE, ADSC, ADSC-Ex and group EW were compared with one another, n = 3 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Techniques: Staining, Light Microscopy, Microscopy

Journal: Scientific Reports

Article Title: Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema

doi: 10.1038/s41598-025-34280-0

Figure Lengend Snippet: ADSC-Ex attenuates fibrosis by suppressing TGF-β1/Smad signaling in edematous skin. ( A ) Representative Western blot images of TGF-β/smad signaling-related proteins in edematous regions, (TGFβ1, Smad2/3, P-Smad2/3 and Smad7). ( B – E ) Representative density analysis of the TGF-β/smad signaling-related proteins in edematous regions, (TGFβ1, Smad2/3, P-Smad2/3 and Smad7). Group Sham, SLE, ADSC, ADSC-Ex and group EW were compared with one another, n = 3 for each group. Ordinary one-way ANOVA and Tukey’s multiple-comparisons test were applied. *P < 0.05, **P 0.01, ***P < 0.001.

Techniques: Western Blot

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